Sensitivity enhancement for diagnostic assays
ProblemThe COVID-19 pandemic has ushered in a new era of diagnostic testing. Patients now demand rapid results, and they want testing to happen in a safe and convenient setting. Regulatory agencies and the biotech industry are working together to meet this need. Fierce competition is emerging among the hundreds of tests that have now received Emergency...
Inventor(s): Yuebing Zheng, Youngsun Kim
Keywords(s): COVID-19, Diagnostics
Category(s): Life sciences > Diagnostic
Potent broad-spectrum antiviral for COVID-19 treatment
Unmet needBroad-spectrum antiviral drugs like remdisivir and niclosamide are promising treatments for COVID-19. Multiple clinical studies of remdisivir have shown benefits such as reduced recovery time. However, in November of 2020 the WHO recommended against the use of remdisivir for COVID-19 treatment based on questions of effectiveness. There remains...
Inventor(s): Hugh Smyth, Ashlee Brunaugh, Zachary Warnken, Hyo-Jong Seo
Keywords(s): Antivirals, COVID-19, Drugs, Infectious disease
Category(s): Life sciences > Pharmaceuticals > Formulation, Life sciences > Pharmaceuticals > Therapeutic, Life sciences > Pharmaceuticals > Small molecule
Br512: an improved DNA polymerase for isothermal amplification assays
Unmet needLoop-mediated isothermal amplification (LAMP) is a technique that allows for nucleic acid amplification without the need for a thermocycler. This technology enables testing for infections practically anywhere. Testing shortages have exacerbated the COVID-19 pandemic, and there is a high demand for tests that can provide rapid results outside...
Inventor(s): Andrew Ellington, Andre Maranhao, Sanchita Bhadra
Keywords(s): COVID-19, Diagnostics, Engineered enzyme, Isothermal amplification, LAMP, Nucleic acid amplification, Point-of-care, Point-of-need, Polymerase
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Research tools > Reagent, Life sciences > Synthetic biology, Life sciences > Diagnostic